The reference is to death. The specific application to humans is not said to be exclusive.
Humans and animals originally ate only plants. Animals (and man) only became predators some time after the Fall.
Rom. 8:18-23 (WEB)
18 For I consider that the sufferings of this present time are not worthy to be compared with the glory which will be revealed toward us.
19 For the creation waits with eager expectation for the children of God to be revealed.
20 For the creation was subjected to vanity, not of its own will, but because of him who subjected it, in hope
21 that the creation itself also will be delivered from the bondage of decay into the liberty of the glory of the children of God.
22 For we know that the whole creation groans and travails in pain together until now.
23 Not only so, but ourselves also, who have the first fruits of the Spirit, even we ourselves groan within ourselves, waiting for adoption, the redemption of our body.
This "groaning" and "bondage of decay" was obviously not part of the "very good", pre-Fall creation.